| 18. Round | 27/06/2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:1 | ||||
| 19. Round | 03/07/2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:4 | ||||
| 20. Round | 08/07/2021 | Chacaritas FC | - | Atlético Santo Domingo | 2:1 | ||||
| 22. Round | 14/07/2021 | Cumbayá | - | Atlético Santo Domingo | 3:1 | ||||
| 25. Round | 28/07/2021 | Atlético Santo Domingo | - | Liga de Portoviejo | 1:1 | ||||
| 31. Round | 08/09/2021 | América de Quito | - | Atlético Santo Domingo | 1:1 | ||||
| 32. Round | 15/09/2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:0 | ||||
| 33. Round | 22/09/2021 | Liga de Portoviejo | - | Atlético Santo Domingo | 3:3 | ||||
| 34. Round | 29/09/2021 | Atlético Santo Domingo | - | El Nacional | 1:1 | ||||
| 35. Round | 06/10/2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 | ||||
| 36. Round | 13/10/2021 | Gualaceo SC | - | Atlético Santo Domingo | 1:0 |
Colombia