| 1. Round | 18/09/2021 | Escorpiones | - | Cafetaleros de Chiapas | 0:1 | ||||
| 2. Round | 25/09/2021 | Cafetaleros de Chiapas | - | Inter Playa | 3:2 |  |
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| 3. Round | 02/10/2021 | Cafetaleros de Chiapas | - | CD Zap | 2:1 | ||||
| 4. Round | 09/10/2021 | Inter de Querétaro | - | Cafetaleros de Chiapas | 0:2 | ||||
| 5. Round | 13/10/2021 | Cafetaleros de Chiapas | - | Montañeses FC | 3:1 | ||||
| 6. Round | 16/10/2021 | Leviatán FC | - | Cafetaleros de Chiapas | 0:7 | |
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| 7. Round | 25/10/2021 | Cafetaleros de Chiapas | - | Sporting Canamy | 1:1 | ||||
| 8. Round | 31/10/2021 | Yalmakan FC | - | Cafetaleros de Chiapas | 0:3 | ||||
| 9. Round | 06/11/2021 | Cafetaleros de Chiapas | - | Lobos ULMX | 1:2 | |
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| 10. Round | 11/11/2021 | Reboceros de La Piedad | - | Cafetaleros de Chiapas | 0:1 | |
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| 11. Round | 14/11/2021 | Cafetaleros de Chiapas | - | Deportivo Dongu | 4:0 | ||||
| 12. Round | 20/11/2021 | Cañoneros FC | - | Cafetaleros de Chiapas | 1:3 | |
Mexico