| 1. Round | 26/07/2021 | CF Monterrey | - | Puebla FC | 1:1 | ||||
| 2. Round | 01/08/2021 | CF Monterrey | - | Pumas UNAM | 2:0 | ||||
| 3. Round | 07/08/2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 4. Round | 15/08/2021 | CF Monterrey | - | CF Pachuca | 3:1 |  |
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| 13. Round | 16/10/2021 | CF Monterrey | - | Club León | 0:1 | ||||
| 14. Round | 19/10/2021 | Gallos Blancos | - | CF Monterrey | 1:0 | ||||
| 16. Round | 01/11/2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 17. Round | 07/11/2021 | CF América | - | CF Monterrey | 0:0 |
Netherlands
