| 1. Round | 11/09/2021 | Frosinone Calcio [Youth] | - | Reggina 1914 [Youth] | 6:2 | ||||
| 2. Round | 18/09/2021 | Reggina 1914 [Youth] | - | Cosenza Calcio [Youth] | 1:0 | ||||
| 3. Round | 24/09/2021 | Ternana Calcio [Youth] | - | Reggina 1914 [Youth] | 1:1 | ||||
| 4. Round | 02/10/2021 | Reggina 1914 [Youth] | - | US Salernitana 1919 [Youth] | 0:2 |  |
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| 5. Round | 16/10/2021 | Reggina 1914 [Youth] | - | Lazio Roma [Youth] | 0:3 | ||||
| 6. Round | 23/10/2021 | Spezia Calcio [Youth] | - | Reggina 1914 [Youth] | 7:2 | ||||
| 7. Round | 30/10/2021 | Reggina 1914 [Youth] | - | FC Crotone [Youth] | 2:4 | ||||
| 10. Round | 27/11/2021 | Ascoli Calcio [Youth] | - | Reggina 1914 [Youth] | 2:0 | ||||
| 11. Round | 04/12/2021 | Reggina 1914 [Youth] | - | Benevento Calcio [Youth] | 1:3 | ||||
| 12. Round | 11/12/2021 | AC Perugia Calcio [Youth] | - | Reggina 1914 [Youth] | 2:0 | ||||
| 13. Round | 19/12/2021 | Reggina 1914 [Youth] | - | Cesena FC [Youth] | 2:1 |
Italy