3. Round | 16/08/2021 | Managua FC | - | Real Estelí FC | 3:0 | ||||
4. Round | 21/08/2021 | Juventus Managua | - | Real Estelí FC | 1:3 | ||||
5. Round | 30/08/2021 | Real Estelí FC | - | ART Municipal Jalapa | 2:0 | ||||
6. Round | 02/09/2021 | Real Estelí FC | - | UNAN Managua | 4:1 | ![]() |
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7. Round | 13/09/2021 | Diriangén FC | - | Real Estelí FC | 3:2 | ||||
9. Round | 26/09/2021 | Club Deportivo Ocotal | - | Real Estelí FC | 1:2 | ![]() |
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12. Round | 17/10/2021 | Real Estelí FC | - | Managua FC | 1:0 |