| 1. Round | 18/07/2010 | Atlético Junior | - | Deportivo Pereira | 2:1 | ||||
| 3. Round | 01/08/2010 | Atlético Junior | - | Deportes Tolima | 1:1 | ||||
| 4. Round | 08/08/2010 | Millonarios | - | Atlético Junior | 1:1 | ||||
| 6. Round | 22/08/2010 | Deportivo Cali | - | Atlético Junior | 2:2 | ||||
| 8. Round | 05/09/2010 | Atlético Junior | - | Independiente Medellín | 1:1 | ||||
| 5. Round | 09/09/2010 | Atlético Junior | - | Atlético Nacional | 4:2 | ||||
| 9. Round | 12/09/2010 | Real Cartagena | - | Atlético Junior | 1:1 | ||||
| 10. Round | 19/09/2010 | Cúcuta Deportivo | - | Atlético Junior | 3:3 |  |
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| 11. Round | 25/09/2010 | Atlético Junior | - | Once Caldas | 2:2 | ||||
| 12. Round | 03/10/2010 | Boyacá Chicó | - | Atlético Junior | 1:0 | ||||
| 13. Round | 10/10/2010 | Atlético Junior | - | Atlético Huila | 1:1 | ||||
| 15. Round | 24/10/2010 | Atlético Junior | - | América de Cali | 0:2 | ||||
| 16. Round | 31/10/2010 | Cortuluá | - | Atlético Junior | 2:0 | ||||
| 17. Round | 07/11/2010 | Atlético Junior | - | Real Cartagena | 1:1 | ||||
| 18. Round | 14/11/2010 | Envigado FC | - | Atlético Junior | 2:2 |
Colombia