| 1. Round | 23/01/2022 | Independiente Medellín | - | Deportes Tolima | 1:0 | ||||
| 2. Round | 27/01/2022 | Patriotas FC | - | Independiente Medellín | 2:0 | ||||
| 3. Round | 30/01/2022 | Independiente Medellín | - | Deportivo Cali | 2:0 | ||||
| 4. Round | 05/02/2022 | Once Caldas | - | Independiente Medellín | 2:1 | ||||
| 5. Round | 08/02/2022 | Independiente Medellín | - | Cortuluá | 3:1 |  |
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| 6. Round | 12/02/2022 | La Equidad | - | Independiente Medellín | 2:0 | ||||
| 7. Round | 17/02/2022 | Independiente Medellín | - | Atlético Junior | 2:0 | ||||
| 8. Round | 19/02/2022 | Santa Fe | - | Independiente Medellín | 1:0 | ||||
| 9. Round | 02/03/2022 | Independiente Medellín | - | Águilas Doradas | 4:0 | ||||
| 10. Round | 07/03/2022 | Atlético Nacional | - | Independiente Medellín | 2:0 | ||||
| 15. Round | 11/04/2022 | Alianza Petrolera | - | Independiente Medellín | 1:1 | ||||
| 16. Round | 18/04/2022 | Independiente Medellín | - | Unión Magdalena | 0:0 | ||||
| 17. Round | 23/04/2022 | Atlético Bucaramanga | - | Independiente Medellín | 2:3 |  |
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| 18. Round | 30/04/2022 | Independiente Medellín | - | Atlético Nacional | 0:0 | ||||
| 20. Round | 15/05/2022 | Independiente Medellín | - | Deportivo Pasto | 1:0 |
Colombia