| 3. Round | 15/08/2021 | Waldhof Mannheim | - | Würzburger Kickers | 1:1 | ||||
| 4. Round | 22/08/2021 | Würzburger Kickers | - | VfL Osnabrück | 1:1 | ||||
| 5. Round | 25/08/2021 | SC Freiburg II | - | Würzburger Kickers | 1:0 | ||||
| 6. Round | 29/08/2021 | Würzburger Kickers | - | 1. FC Saarbrücken | 1:1 | ||||
| 11. Round | 03/10/2021 | Borussia Dortmund II | - | Würzburger Kickers | 2:0 |  |
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| 16. Round | 21/11/2021 | FC Viktoria 1889 Berlin | - | Würzburger Kickers | 1:1 | |
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| 17. Round | 27/11/2021 | Würzburger Kickers | - | SV Meppen | 1:3 | ||||
| 15. Round | 30/11/2021 | Würzburger Kickers | - | Eintracht Braunschweig | 0:2 |
Bulgaria