| 1. Round | 14/03/2021 | Sputnik Rechytsa | - | Dinamo Brest | 0:4 | ||||
| 2. Round | 20/03/2021 | Dinamo Brest | - | BATE Borisov | 0:0 | ||||
| 3. Round | 02/04/2021 | Neman Grodno | - | Dinamo Brest | 0:1 |  |
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| 5. Round | 17/04/2021 | Torpedo-BelAZ Zhodino | - | Dinamo Brest | 0:2 | ||||
| 6. Round | 24/04/2021 | Dinamo Brest | - | FK Vitebsk | 0:0 | ||||
| 7. Round | 29/04/2021 | FK Slutsk | - | Dinamo Brest | 1:1 | ||||
| 8. Round | 08/05/2021 | FK Slaviya Mozyr | - | Dinamo Brest | 1:1 | ||||
| 9. Round | 16/05/2021 | Dinamo Brest | - | FK Gomel | 1:0 | ||||
| 10. Round | 22/05/2021 | FK Minsk | - | Dinamo Brest | 1:0 | ||||
| 11. Round | 30/05/2021 | Dinamo Brest | - | Energetik-BGU Minsk | 0:1 | ||||
| 12. Round | 13/06/2021 | FK Isloch Minsk | - | Dinamo Brest | 1:1 | ||||
| 13. Round | 18/06/2021 | Dinamo Brest | - | FK Smorgon | 2:2 | ||||
| 14. Round | 26/06/2021 | Shakhter Soligorsk | - | Dinamo Brest | 1:1 | ||||
| 15. Round | 04/07/2021 | Dinamo Brest | - | Rukh Brest | 1:1 | ||||
| 24. Round | 24/09/2021 | FK Gomel | - | Dinamo Brest | 0:0 | ||||
| 26. Round | 17/10/2021 | Energetik-BGU Minsk | - | Dinamo Brest | 0:0 | ||||
| 27. Round | 23/10/2021 | Dinamo Brest | - | FK Isloch Minsk | 1:0 |
Belarus