| 1. Round | 13/03/2021 | FK Turan | - | FK Astana | 2:2 | ||||
| 9. Round | 02/05/2021 | FK Aktobe | - | FK Astana | 0:2 | ||||
| 16. Round | 18/06/2021 | FK Atyrau | - | FK Astana | 0:2 | ||||
| 18. Round | 27/06/2021 | FK Kyzylzhar | - | FK Astana | 3:2 | ||||
| 19. Round | 02/07/2021 | FK Astana | - | Shakter Karaganda | 4:3 | ||||
| 20. Round | 11/09/2021 | FK Akzhayik | - | FK Astana | 0:1 | ||||
| 22. Round | 27/09/2021 | FK Astana | - | FK Taraz | 3:0 | ||||
| 23. Round | 02/10/2021 | Zhetysu Taldykorgan | - | FK Astana | 1:3 | ||||
| 24. Round | 17/10/2021 | FK Astana | - | Kaysar Kyzylorda | 2:0 | ||||
| 25. Round | 24/10/2021 | FK Kairat | - | FK Astana | 1:0 | ||||
| 26. Round | 30/10/2021 | FK Astana | - | FK Turan | 1:1 |
Kazakhstan