| 1. Round | 24/07/2021 | KV Kortrijk | - | RFC Seraing | 2:0 | ||||
| 2. Round | 31/07/2021 | RFC Seraing | - | KV Mechelen | 1:0 | ||||
| 3. Round | 08/08/2021 | RSC Anderlecht | - | RFC Seraing | 3:0 | ||||
| 4. Round | 14/08/2021 | RFC Seraing | - | KV Oostende | 2:3 | ||||
| 5. Round | 21/08/2021 | RFC Seraing | - | Cercle Brugge | 2:1 |  |
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| 6. Round | 28/08/2021 | KAS Eupen | - | RFC Seraing | 1:2 | ||||
| 7. Round | 12/09/2021 | RFC Seraing | - | Standard Liège | 0:1 | ||||
| 8. Round | 19/09/2021 | Royal Antwerp FC | - | RFC Seraing | 2:1 | ||||
| 9. Round | 26/09/2021 | KRC Genk | - | RFC Seraing | 3:0 | |
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| 12. Round | 22/10/2021 | RFC Seraing | - | Sporting Charleroi | 1:3 | ||||
| 14. Round | 07/11/2021 | RFC Seraing | - | KAA Gent | 0:0 | |
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| 15. Round | 20/11/2021 | Oud-Heverlee Leuven | - | RFC Seraing | 1:3 | ||||
| 18. Round | 11/12/2021 | RFC Seraing | - | RSC Anderlecht | 0:5 | ||||
| 26. Round | 04/02/2022 | Sporting Charleroi | - | RFC Seraing | 2:0 | ||||
| 28. Round | 23/02/2022 | KAA Gent | - | RFC Seraing | 4:0 | ||||
| 29. Round | 27/02/2022 | SV Zulte Waregem | - | RFC Seraing | 1:0 | ||||
| 30. Round | 05/03/2022 | RFC Seraing | - | Club Brugge KV | 0:5 | ||||
| 34. Round | 10/04/2022 | RFC Seraing | - | KRC Genk | 0:2 |
Senegal