| 1. Round | 22/08/2021 | Bologna FC | - | US Salernitana 1919 | 3:2 | ||||
| 2. Round | 29/08/2021 | US Salernitana 1919 | - | AS Roma | 0:4 | ||||
| 3. Round | 12/09/2021 | Torino FC | - | US Salernitana 1919 | 4:0 | ||||
| 4. Round | 18/09/2021 | US Salernitana 1919 | - | Atalanta | 0:1 | ||||
| 5. Round | 22/09/2021 | US Salernitana 1919 | - | Hellas Verona | 2:2 | ||||
| 8. Round | 16/10/2021 | Spezia Calcio | - | US Salernitana 1919 | 2:1 | ||||
| 9. Round | 23/10/2021 | US Salernitana 1919 | - | Empoli FC | 2:4 | ||||
| 10. Round | 26/10/2021 | Venezia FC | - | US Salernitana 1919 | 1:2 | ||||
| 12. Round | 07/11/2021 | Lazio Roma | - | US Salernitana 1919 | 3:0 | ||||
| 13. Round | 21/11/2021 | US Salernitana 1919 | - | Sampdoria | 0:2 | ||||
| 14. Round | 26/11/2021 | Cagliari Calcio | - | US Salernitana 1919 | 1:1 | ||||
| 15. Round | 30/11/2021 | US Salernitana 1919 | - | Juventus | 0:2 | ||||
| 16. Round | 04/12/2021 | AC Milan | - | US Salernitana 1919 | 2:0 | ||||
| 17. Round | 11/12/2021 | ACF Fiorentina | - | US Salernitana 1919 | 4:0 | ||||
| 21. Round | 09/01/2022 | Hellas Verona | - | US Salernitana 1919 | 1:2 | ||||
| 22. Round | 15/01/2022 | US Salernitana 1919 | - | Lazio Roma | 0:3 | ||||
| 23. Round | 23/01/2022 | SSC Napoli | - | US Salernitana 1919 | 4:1 |
France