| 5. Round | 25/11/2021 | US Biskra | - | HB Chelghoum Laïd | 2:0 | ||||
| 7. Round | 10/12/2021 | US Biskra | - | ASO Chlef | 2:1 | ||||
| 11. Round | 03/01/2022 | US Biskra | - | WA Tlemcen | 0:0 |  |
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| 12. Round | 07/01/2022 | MC Alger | - | US Biskra | 1:1 | ||||
| 6. Round | 11/01/2022 | JS Kabylie | - | US Biskra | 1:1 | |
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| 13. Round | 16/01/2022 | US Biskra | - | CS Constantine | 2:0 | |
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| 14. Round | 21/01/2022 | Paradou AC | - | US Biskra | 1:0 | ||||
| 15. Round | 25/01/2022 | US Biskra | - | Olympique Médéa | 2:1 | |
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| 17. Round | 05/02/2022 | US Biskra | - | NA Hussein Dey | 2:1 | ||||
| 18. Round | 25/02/2022 | US Biskra | - | RC Arbaâ | 1:0 | ||||
| 20. Round | 05/03/2022 | RC Rélizane | - | US Biskra | 1:1 | ||||
| 22. Round | 18/03/2022 | HB Chelghoum Laïd | - | US Biskra | 3:1 | ||||
| 19. Round | 24/03/2022 | JS Saoura | - | US Biskra | 2:0 | ||||
| 23. Round | 28/03/2022 | US Biskra | - | JS Kabylie | 0:1 | ||||
| 24. Round | 01/04/2022 | ASO Chlef | - | US Biskra | 2:0 | ||||
| 25. Round | 13/04/2022 | US Biskra | - | MC Oran | 2:2 | ||||
| 26. Round | 31/05/2022 | CR Bélouizdad | - | US Biskra | 2:0 |
Algeria