| 2. Round | 25/07/2021 | Atlético Junior | - | Envigado FC | 1:0 |  |
|||
| 3. Round | 01/08/2021 | Independiente Medellín | - | Atlético Junior | 0:0 | ||||
| 4. Round | 09/08/2021 | Atlético Junior | - | Deportes Tolima | 0:0 | ||||
| 5. Round | 15/08/2021 | Jaguares de Córdoba | - | Atlético Junior | 1:1 | ||||
| 6. Round | 22/08/2021 | Atlético Junior | - | Once Caldas | 4:2 | ||||
| 8. Round | 23/09/2021 | Atlético Junior | - | Atlético Huila | 3:0 | ||||
| 11. Round | 25/09/2021 | Águilas Doradas | - | Atlético Junior | 1:2 | |
|||
| 12. Round | 02/10/2021 | Atlético Junior | - | Patriotas FC | 1:0 | ||||
| 13. Round | 12/10/2021 | Atlético Bucaramanga | - | Atlético Junior | 1:1 | |
|||
| 14. Round | 18/10/2021 | Atlético Junior | - | Jaguares de Córdoba | 2:1 | ||||
| 15. Round | 24/10/2021 | Millonarios | - | Atlético Junior | 4:1 | |
|||
| 20. Round | 21/11/2021 | Alianza Petrolera | - | Atlético Junior | 1:1 |
Colombia