| 1. Round | 23/01/2022 | Atlético Junior | - | Patriotas FC | 3:1 | ||||
| 2. Round | 27/01/2022 | Atlético Nacional | - | Atlético Junior | 3:1 | ||||
| 3. Round | 29/01/2022 | Atlético Junior | - | La Equidad | 1:0 |  |
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| 4. Round | 03/02/2022 | Santa Fe | - | Atlético Junior | 2:1 | ||||
| 10. Round | 05/03/2022 | Atlético Junior | - | Unión Magdalena | 3:1 | ||||
| 11. Round | 20/03/2022 | Deportivo Pereira | - | Atlético Junior | 1:0 | ||||
| 15. Round | 10/04/2022 | Deportivo Cali | - | Atlético Junior | 1:1 | ||||
| 16. Round | 17/04/2022 | Atlético Junior | - | Atlético Bucaramanga | 2:0 | ||||
| 18. Round | 02/05/2022 | Atlético Junior | - | Envigado FC | 4:0 | ||||
| 20. Round | 15/05/2022 | Atlético Junior | - | Jaguares de Córdoba | 2:4 | |
Colombia