| 1. Round | 08/07/2022 | Patriotas FC | - | Atlético Junior | 1:0 | ||||
| 2. Round | 14/07/2022 | Atlético Junior | - | Atlético Nacional | 3:1 | ||||
| 3. Round | 17/07/2022 | La Equidad | - | Atlético Junior | 0:0 | ||||
| 4. Round | 24/07/2022 | Atlético Junior | - | Santa Fe | 2:0 | ||||
| 6. Round | 08/08/2022 | Atlético Junior | - | Once Caldas | 1:2 | ||||
| 7. Round | 14/08/2022 | Atlético Junior | - | Independiente Medellín | 4:2 |  |
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| 9. Round | 29/08/2022 | Atlético Junior | - | Deportes Tolima | 2:1 | ||||
| 10. Round | 04/09/2022 | Unión Magdalena | - | Atlético Junior | 2:1 |  |
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| 11. Round | 10/09/2022 | Atlético Junior | - | Deportivo Pereira | 0:0 | ||||
| 12. Round | 18/09/2022 | Deportivo Pasto | - | Atlético Junior | 2:1 | ||||
| 13. Round | 22/09/2022 | Atlético Junior | - | Millonarios | 0:1 | |
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| 14. Round | 26/09/2022 | Alianza Petrolera | - | Atlético Junior | 0:1 | ||||
| 15. Round | 02/10/2022 | Atlético Junior | - | Deportivo Cali | 1:0 | ||||
| 16. Round | 10/10/2022 | Atlético Bucaramanga | - | Atlético Junior | 0:1 | |
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| 17. Round | 14/10/2022 | Atlético Junior | - | Unión Magdalena | 1:1 | |
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| 18. Round | 17/10/2022 | Envigado FC | - | Atlético Junior | 2:0 |
Colombia