| 2. Round | 08/08/2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 |  |
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| 3. Round | 11/08/2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 4. Round | 15/08/2021 | Municipal Limeño | - | FAS | 0:3 | ||||
| 5. Round | 22/08/2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | ||||
| 6. Round | 25/08/2021 | Municipal Limeño | - | Atlético Marte | 1:2 | |
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| 7. Round | 29/08/2021 | Santa Tecla FC | - | Municipal Limeño | 1:1 | ||||
| 8. Round | 12/09/2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Round | 15/09/2021 | Jocoro FC | - | Municipal Limeño | 3:1 | ||||
| 10. Round | 19/09/2021 | AD Chalatenango | - | Municipal Limeño | 1:1 | |
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| 12. Round | 02/10/2021 | Municipal Limeño | - | Alianza | 0:3 | |
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| 14. Round | 09/10/2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 15. Round | 24/10/2021 | FAS | - | Municipal Limeño | 2:1 | ||||
| 21. Round | 21/11/2021 | Municipal Limeño | - | AD Chalatenango | 0:3 | ||||
| 22. Round | 27/11/2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 | |
El Salvador