| 1. Round | 10/07/2022 | H&H Export Sébaco | - | Juventus Managua | 0:0 | ||||
| 3. Round | 24/07/2022 | Juventus Managua | - | Matagalpa FC | 3:2 | ||||
| 4. Round | 31/07/2022 | Diriangén FC | - | Juventus Managua | 2:0 | ||||
| 6. Round | 12/08/2022 | UNAN Managua | - | Juventus Managua | 2:1 | ||||
| 12. Round | 01/10/2022 | Matagalpa FC | - | Juventus Managua | 2:5 |  |
|||
| 15. Round | 31/10/2022 | Juventus Managua | - | UNAN Managua | 2:1 | ||||
| 16. Round | 13/11/2022 | CD Walter Ferretti | - | Juventus Managua | 2:1 | ||||
| 17. Round | 21/11/2022 | ART Municipal Jalapa | - | Juventus Managua | 2:0 | ||||
| 18. Round | 30/11/2022 | Juventus Managua | - | Club Deportivo Ocotal | 9:0 |
Nicaragua