| 1. Round | 24/01/2021 | Junior Managua | - | Managua FC | 1:3 | ||||
| 4. Round | 03/02/2021 | Managua FC | - | Real Madriz | 4:1 | ||||
| 5. Round | 07/02/2021 | Juventus Managua | - | Managua FC | 0:5 | ||||
| 7. Round | 14/02/2021 | CD Walter Ferretti | - | Managua FC | 2:1 | ||||
| 8. Round | 17/02/2021 | Managua FC | - | Diriangén FC | 1:3 |  |
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| 9. Round | 01/03/2021 | Real Estelí FC | - | Managua FC | 1:1 | ||||
| 10. Round | 07/03/2021 | Managua FC | - | Junior Managua | 3:1 | ||||
| 12. Round | 01/04/2021 | Managua FC | - | Chinandega | 3:1 | ||||
| 13. Round | 15/04/2021 | Real Madriz | - | Managua FC | 1:0 | |
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| 16. Round | 29/04/2021 | Managua FC | - | CD Walter Ferretti | 3:1 | ||||
| 17. Round | 02/05/2021 | Diriangén FC | - | Managua FC | 4:1 | |
Nicaragua