| 1. Round | 26/06/2022 | Leones Negros | - | Alebrijes de Oaxaca | 0:0 | ||||
| 2. Round | 11/07/2022 | Leones Negros | - | Tepatitlán | 3:0 | ||||
| 3. Round | 14/07/2022 | Atlético La Paz | - | Leones Negros | 2:2 | ||||
| 4. Round | 22/07/2022 | Leones Negros | - | Correcaminos UAT | 0:0 | ||||
| 5. Round | 31/07/2022 | Tapatío | - | Leones Negros | 0:2 | ||||
| 6. Round | 08/08/2022 | Leones Negros | - | Venados FC | 4:0 | ||||
| 7. Round | 11/08/2022 | Cimarrones de Sonora | - | Leones Negros | 2:1 |  |
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| 8. Round | 17/08/2022 | Alacranes de Durango | - | Leones Negros | 1:0 | |
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| 9. Round | 23/08/2022 | Leones Negros | - | Mineros de Zacatecas | 3:2 | ||||
| 10. Round | 01/09/2022 | Coyotes de Tlaxcala | - | Leones Negros | 2:0 | ||||
| 11. Round | 06/09/2022 | Leones Negros | - | Cancún FC | 3:0 | ||||
| 12. Round | 14/09/2022 | Pumas Tabasco | - | Leones Negros | 0:2 |  |
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| 13. Round | 21/09/2022 | CF Monterrey II | - | Leones Negros | 0:1 | |
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| 14. Round | 26/09/2022 | Leones Negros | - | Atlante | 2:2 | |
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| 15. Round | 29/09/2022 | Dorados de Sinaloa | - | Leones Negros | 0:2 | ||||
| 16. Round | 04/10/2022 | Leones Negros | - | Club Celaya | 0:2 | ||||
| 17. Round | 14/10/2022 | Atlético Morelia | - | Leones Negros | 0:1 | |
Colombia