| 12. Round | 21/11/2021 | KMSK Deinze | - | Lommel SK | 3:3 | ||||
| 13. Round | 28/11/2021 | RWD Molenbeek | - | KMSK Deinze | 2:2 | ||||
| 14. Round | 03/12/2021 | KMSK Deinze | - | Excelsior Virton | 3:0 | ||||
| 15. Round | 12/12/2021 | Waasland-Beveren | - | KMSK Deinze | 4:1 | ||||
| 16. Round | 18/12/2021 | KMSK Deinze | - | Royal Excel Mouscron | 2:2 | ||||
| 23. Round | 04/03/2022 | KMSK Deinze | - | KVC Westerlo | 1:2 |  |
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| 28. Round | 16/04/2022 | Lommel SK | - | KMSK Deinze | 2:1 |
France