| 1. Round | 20/07/2019 | CF Pachuca | - | Club León | 1:3 | ||||
| 2. Round | 28/07/2019 | Club León | - | CF América | 0:0 | ||||
| 3. Round | 04/08/2019 | CF Monterrey | - | Club León | 3:2 | ||||
| 5. Round | 18/08/2019 | Club León | - | Deportivo Guadalajara | 4:3 | ||||
| 6. Round | 24/08/2019 | Gallos Blancos | - | Club León | 0:4 |  |
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| 7. Round | 29/08/2019 | Club León | - | Santos Laguna | 2:2 | ||||
| 8. Round | 01/09/2019 | UANL Tigres | - | Club León | 1:1 | |
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| 9. Round | 15/09/2019 | Club León | - | FC Juárez | 3:1 |  |
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| 10. Round | 21/09/2019 | Club Necaxa | - | Club León | 2:4 | ||||
| 11. Round | 25/09/2019 | Club León | - | Atlas Guadalajara | 1:1 | ||||
| 13. Round | 05/10/2019 | Club León | - | CD Veracruz | 1:1 | |
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| 14. Round | 20/10/2019 | Pumas UNAM | - | Club León | 1:2 | |
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| 15. Round | 27/10/2019 | Club León | - | Atlético San Luis | 3:2 | ||||
| 16. Round | 01/11/2019 | Cruz Azul | - | Club León | 1:0 | ||||
| 17. Round | 04/11/2019 | Club León | - | Monarcas Morelia | 1:1 | |
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| 18. Round | 10/11/2019 | Club León | - | Deportivo Toluca | 4:0 |
Colombia