| 1. Round | 26/07/2020 | Deportivo Guadalajara | - | Club León | 0:0 | ||||
| 2. Round | 04/08/2020 | Club León | - | CF Monterrey | 1:0 |  |
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| 3. Round | 09/08/2020 | Cruz Azul | - | Club León | 2:0 | ||||
| 4. Round | 12/08/2020 | CF Pachuca | - | Club León | 0:1 | ||||
| 5. Round | 18/08/2020 | Club León | - | Club Tijuana | 2:1 | ||||
| 7. Round | 01/09/2020 | Club León | - | Atlas Guadalajara | 2:1 | |
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| 8. Round | 05/09/2020 | Club Necaxa | - | Club León | 0:2 | ||||
| 9. Round | 09/09/2020 | Club León | - | UANL Tigres | 1:1 | |
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| 10. Round | 14/09/2020 | Gallos Blancos | - | Club León | 2:3 | ||||
| 11. Round | 22/09/2020 | Club León | - | Pumas UNAM | 2:0 | ||||
| 12. Round | 27/09/2020 | Atlético San Luis | - | Club León | 0:2 | ||||
| 13. Round | 03/10/2020 | Club León | - | Mazatlán FC | 2:1 | |
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| 14. Round | 20/10/2020 | Club León | - | CF América | 3:2 | ||||
| 15. Round | 24/10/2020 | Puebla FC | - | Club León | 1:2 | ||||
| 16. Round | 03/11/2020 | Club León | - | Santos Laguna | 2:1 | |
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| 17. Round | 08/11/2020 | Deportivo Toluca | - | Club León | 2:2 |
Colombia