3. Round | 19/02/2022 | Cerro Porteño | - | Guaraní | 2:0 | ||||
6. Round | 13/03/2022 | Cerro Porteño | - | Club Olimpia | 0:2 | ||||
7. Round | 19/03/2022 | Resistencia SC | - | Cerro Porteño | 0:3 | ||||
9. Round | 09/04/2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
12. Round | 24/04/2022 | Sportivo Ameliano | - | Cerro Porteño | 0:1 | ||||
13. Round | 01/05/2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
15. Round | 12/05/2022 | Cerro Porteño | - | Guaireña FC | 0:0 | ||||
17. Round | 22/05/2022 | Club Olimpia | - | Cerro Porteño | 0:4 |