| 2. Round | 25/04/2021 | Universidad Central | - | Monagas | 0:2 |  |
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| 3. Round | 30/04/2021 | Atlético Venezuela | - | Universidad Central | 1:1 | ||||
| 5. Round | 15/05/2021 | Universidad Central | - | LALA FC | 2:0 | ||||
| 7. Round | 29/05/2021 | Mineros de Guayana | - | Universidad Central | 3:1 | ||||
| 8. Round | 03/06/2021 | Universidad Central | - | Caracas FC | 2:3 | ||||
| 9. Round | 14/06/2021 | Monagas | - | Universidad Central | 4:0 | ||||
| 15. Round | 25/07/2021 | Caracas FC | - | Universidad Central | 2:1 | ||||
| 16. Round | 31/07/2021 | Universidad Central | - | Monagas | 3:0 | ||||
| 22. Round | 08/09/2021 | Universidad Central | - | Caracas FC | 1:1 | |
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| 26. Round | 05/10/2021 | LALA FC | - | Universidad Central | 0:1 |
Venezuela