| 3. Round | 26/01/2022 | Once Municipal | - | Municipal Limeño | 3:2 | ||||
| 4. Round | 30/01/2022 | Municipal Limeño | - | CD Águila | 0:3 | ||||
| 5. Round | 04/02/2022 | Jocoro FC | - | Municipal Limeño | 3:0 | ||||
| 6. Round | 09/02/2022 | Municipal Limeño | - | FAS | 1:1 | ||||
| 7. Round | 13/02/2022 | Santa Tecla FC | - | Municipal Limeño | 1:1 | ||||
| 8. Round | 20/02/2022 | Municipal Limeño | - | Alianza | 0:0 | ||||
| 9. Round | 23/02/2022 | Municipal Limeño | - | Atlético Marte | 2:0 | ||||
| 10. Round | 27/02/2022 | Isidro Metapán | - | Municipal Limeño | 2:0 | ||||
| 11. Round | 06/03/2022 | Municipal Limeño | - | AD Chalatenango | 0:1 | ||||
| 12. Round | 13/03/2022 | Municipal Limeño | - | Luis Ángel Firpo | 3:2 |  |
|||
| 13. Round | 20/03/2022 | Platense Zacatecoluca | - | Municipal Limeño | 1:0 | ||||
| 18. Round | 17/04/2022 | Municipal Limeño | - | Santa Tecla FC | 2:0 | ||||
| 19. Round | 24/04/2022 | Alianza | - | Municipal Limeño | 4:0 |
Colombia