| 3. Round | 22/01/2022 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Round | 04/02/2022 | Guadalupe | - | AD San Carlos | 3:1 | ||||
| 5. Round | 11/02/2022 | AD San Carlos | - | CS Herediano | 1:1 | ||||
| 20. Round | 09/05/2022 | AD San Carlos | - | CS Cartaginés | 3:2 | ||||
| 21. Round | 13/05/2022 | LD Alajuelense | - | AD San Carlos | 1:0 | ||||
| 22. Round | 15/05/2022 | AD San Carlos | - | Sporting FC | 2:1 |
Panama