| 2. Round | 30/07/2018 | Club León | - | CF Monterrey | 0:2 | ||||
| 3. Round | 06/08/2018 | Club Tijuana | - | Club León | 1:1 |  |
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| 4. Round | 12/08/2018 | Club León | - | Gallos Blancos | 4:0 |  |
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| 5. Round | 18/08/2018 | Cruz Azul | - | Club León | 3:0 | ||||
| 6. Round | 23/08/2018 | Club León | - | CF América | 2:0 | ||||
| 7. Round | 26/08/2018 | Deportivo Toluca | - | Club León | 1:2 | ||||
| 8. Round | 02/09/2018 | Club León | - | Pumas UNAM | 1:2 | ||||
| 9. Round | 16/09/2018 | Santos Laguna | - | Club León | 3:0 | ||||
| 10. Round | 23/09/2018 | Club León | - | Lobos BUAP | 0:1 | ||||
| 11. Round | 29/09/2018 | CD Veracruz | - | Club León | 0:4 | ||||
| 12. Round | 07/10/2018 | Club León | - | Monarcas Morelia | 1:2 | ||||
| 14. Round | 29/10/2018 | Club León | - | Puebla FC | 0:4 | ||||
| 15. Round | 05/11/2018 | Atlas Guadalajara | - | Club León | 0:0 | ||||
| 16. Round | 11/11/2018 | Club León | - | Deportivo Guadalajara | 0:1 | ||||
| 17. Round | 25/11/2018 | CF Pachuca | - | Club León | 1:1 |
Colombia