| 1. Round | 06/01/2019 | Club León | - | UANL Tigres | 2:2 |  |
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| 2. Round | 12/01/2019 | CF Monterrey | - | Club León | 2:2 | ||||
| 4. Round | 27/01/2019 | Gallos Blancos | - | Club León | 0:4 | ||||
| 5. Round | 03/02/2019 | Club León | - | Cruz Azul | 2:0 | ||||
| 12. Round | 30/03/2019 | Monarcas Morelia | - | Club León | 2:3 | ||||
| 14. Round | 13/04/2019 | Puebla FC | - | Club León | 0:3 | ||||
| 15. Round | 20/04/2019 | Club León | - | Atlas Guadalajara | 5:2 | ||||
| 16. Round | 28/04/2019 | Deportivo Guadalajara | - | Club León | 2:1 | ||||
| 17. Round | 05/05/2019 | Club León | - | CF Pachuca | 2:1 |
Colombia