| 2. Round | 17/01/2023 | Club León | - | Club Necaxa | 2:1 | ||||
| 3. Round | 22/01/2023 | Pumas UNAM | - | Club León | 4:1 | ||||
| 4. Round | 29/01/2023 | Deportivo Toluca | - | Club León | 0:0 | ||||
| 5. Round | 04/02/2023 | Club León | - | CF Pachuca | 0:1 | ||||
| 6. Round | 10/02/2023 | Gallos Blancos | - | Club León | 0:3 |  |
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| 7. Round | 15/02/2023 | Club León | - | Puebla FC | 2:0 | ||||
| 8. Round | 18/02/2023 | FC Juárez | - | Club León | 0:0 | ||||
| 9. Round | 28/02/2023 | Club León | - | CF Monterrey | 1:1 | ||||
| 10. Round | 04/03/2023 | Club León | - | Atlético San Luis | 2:0 | ||||
| 11. Round | 11/03/2023 | Atlas Guadalajara | - | Club León | 0:1 |  |
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| 12. Round | 20/03/2023 | Club León | - | Santos Laguna | 4:1 | ||||
| 17. Round | 01/05/2023 | Club León | - | UANL Tigres | 3:0 |
Colombia