| 19. Round | 14/08/2021 | FK Vitebsk | - | FK Slaviya Mozyr | 2:2 |  |
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| 20. Round | 20/08/2021 | FK Slutsk | - | FK Vitebsk | 1:2 | ||||
| 21. Round | 29/08/2021 | FK Vitebsk | - | Dinamo Brest | 3:1 | ||||
| 22. Round | 11/09/2021 | FK Gomel | - | FK Vitebsk | 4:1 | ||||
| 23. Round | 19/09/2021 | FK Vitebsk | - | FK Minsk | 3:1 | ||||
| 25. Round | 02/10/2021 | FK Vitebsk | - | FK Isloch Minsk | 0:4 | ||||
| 26. Round | 16/10/2021 | FK Smorgon | - | FK Vitebsk | 2:0 | ||||
| 27. Round | 23/10/2021 | FK Vitebsk | - | Shakhter Soligorsk | 1:2 | ||||
| 28. Round | 05/11/2021 | Rukh Brest | - | FK Vitebsk | 2:0 | ||||
| 30. Round | 28/11/2021 | BATE Borisov | - | FK Vitebsk | 4:0 |
Belarus