| 2. Round | 23/01/2021 | Llaneros FC | - | Deportes Quindío | 0:1 | ||||
| 3. Round | 31/01/2021 | Deportes Quindío | - | Unión Magdalena | 1:0 | ||||
| 4. Round | 07/02/2021 | Tigres FC | - | Deportes Quindío | 1:1 | ||||
| 5. Round | 10/02/2021 | Orsomarso SC | - | Deportes Quindío | 2:1 | ||||
| 6. Round | 16/02/2021 | Deportes Quindío | - | Boca Juniors de Cali | 1:1 | ||||
| 7. Round | 19/02/2021 | Real Cartagena | - | Deportes Quindío | 2:3 | ||||
| 8. Round | 28/02/2021 | Real Santander | - | Deportes Quindío | 1:1 | ||||
| 9. Round | 04/03/2021 | Bogotá FC | - | Deportes Quindío | 1:1 | ||||
| 10. Round | 07/03/2021 | Deportes Quindío | - | Fortaleza FC | 2:1 | ||||
| 11. Round | 14/03/2021 | Leones FC | - | Deportes Quindío | 0:2 | ||||
| 12. Round | 22/03/2021 | Deportes Quindío | - | Atlético Huila | 0:0 | ||||
| 13. Round | 26/03/2021 | Cortuluá | - | Deportes Quindío | 0:0 |  |
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| 14. Round | 03/04/2021 | Deportes Quindío | - | Atlético FC | 1:0 | ||||
| 15. Round | 09/04/2021 | Barranquilla FC | - | Deportes Quindío | 0:0 | |
Colombia