| 12. Round | 20/11/2021 | US Colomiers | - | Moulins Yzeure Foot | 0:1 | ||||
| 14. Round | 11/12/2021 | Canet Roussillon | - | Moulins Yzeure Foot | 1:2 | ||||
| 17. Round | 05/02/2022 | AS Béziers | - | Moulins Yzeure Foot | 3:2 | ||||
| 18. Round | 12/02/2022 | Moulins Yzeure Foot | - | Stade Montois | 2:0 |  |
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| 19. Round | 19/02/2022 | Bourges Foot 18 | - | Moulins Yzeure Foot | 1:1 | ||||
| 21. Round | 12/03/2022 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 | ||||
| 22. Round | 19/03/2022 | Moulins Yzeure Foot | - | Vendée Les Herbiers | 0:1 | |
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| 23. Round | 26/03/2022 | Montpellier HSC B | - | Moulins Yzeure Foot | 4:2 | |
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| 25. Round | 16/04/2022 | Andrézieux-Bouthéon FC | - | Moulins Yzeure Foot | 2:0 | ||||
| 26. Round | 23/04/2022 | Moulins Yzeure Foot | - | US Colomiers | 3:1 | ||||
| 28. Round | 14/05/2022 | Moulins Yzeure Foot | - | Canet Roussillon | 1:2 |
France
Martinique