| 1. Round | 07/08/2021 | RC Grasse | - | Lyon-La Duchère | 1:0 | ||||
| 2. Round | 14/08/2021 | Lyon-La Duchère | - | Louhans-Cuiseaux | 1:3 | ||||
| 3. Round | 21/08/2021 | Hyères FC | - | Lyon-La Duchère | 0:0 | ||||
| 4. Round | 27/08/2021 | SC Toulon | - | Lyon-La Duchère | 0:2 |  |
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| 5. Round | 04/09/2021 | Lyon-La Duchère | - | AS Monaco B | 0:2 | ||||
| 6. Round | 11/09/2021 | FC Martigues | - | Lyon-La Duchère | 0:3 | |
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| 7. Round | 18/09/2021 | Lyon-La Duchère | - | GFA Rumilly Vallières | 0:0 | |
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| 8. Round | 25/09/2021 | AS Saint-Priest | - | Lyon-La Duchère | 1:2 | ||||
| 9. Round | 09/10/2021 | Lyon-La Duchère | - | Étoile FC | 0:1 | ||||
| 10. Round | 23/10/2021 | GOAL FC | - | Lyon-La Duchère | 5:1 |
Belgium
Congo