| 20. Round | 21/02/2022 | Pirin Blagoevgrad | - | Lokomotiv Sofia | 2:1 | ||||
| 21. Round | 28/02/2022 | Pirin Blagoevgrad | - | Arda Kardzhali | 1:0 |  |
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| 22. Round | 05/03/2022 | Cherno More Varna | - | Pirin Blagoevgrad | 1:1 | ||||
| 23. Round | 14/03/2022 | Pirin Blagoevgrad | - | Slavia Sofia | 0:0 | ||||
| 24. Round | 20/03/2022 | Botev Vratsa | - | Pirin Blagoevgrad | 0:3 | ||||
| 25. Round | 03/04/2022 | Pirin Blagoevgrad | - | Levski Sofia | 0:3 | ||||
| 26. Round | 11/04/2022 | Tsarsko Selo Sofia | - | Pirin Blagoevgrad | 1:0 |
Bulgaria