1. Round | 06/02/2022 | Guaireña FC | - | Guaraní | 0:0 | ||||
2. Round | 12/02/2022 | Guaireña FC | - | Club Olimpia | 1:3 | ||||
5. Round | 05/03/2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
7. Round | 21/03/2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
8. Round | 02/04/2022 | Guaireña FC | - | Libertad | 2:3 | ||||
11. Round | 20/04/2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 | ||||
20. Round | 24/06/2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
21. Round | 27/06/2022 | Sportivo Ameliano | - | Guaireña FC | 2:2 | ||||
22. Round | 01/07/2022 | Guaireña FC | - | Club Nacional | 1:1 |