| 4. Round | 27/02/2021 | Marathón | - | Real España | 1:2 | ||||
| 5. Round | 05/03/2021 | Real España | - | Vida | 0:0 | ||||
| 6. Round | 08/03/2021 | Olimpia | - | Real España | 1:0 | ||||
| 8. Round | 18/03/2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 9. Round | 21/03/2021 | Real España | - | Marathón | 2:2 | ||||
| 10. Round | 04/04/2021 | Vida | - | Real España | 2:3 | ||||
| 2. Round | 08/04/2021 | Platense | - | Real España | 2:2 | ||||
| 11. Round | 11/04/2021 | Real de Minas | - | Real España | 0:0 | ||||
| 12. Round | 18/04/2021 | Motagua | - | Real España | 1:0 | ||||
| 13. Round | 22/04/2021 | Real España | - | Lobos UPNFM | 1:1 | ||||
| 14. Round | 28/04/2021 | Real España | - | Real Sociedad | 0:0 |
Honduras