| 1. Round | 04/10/2020 | Honduras Progreso | - | Marathón | 1:1 | ||||
| 2. Round | 08/10/2020 | Honduras Progreso | - | Vida | 1:1 | ||||
| 3. Round | 12/10/2020 | Real España | - | Honduras Progreso | 5:0 | ||||
| 7. Round | 25/10/2020 | Vida | - | Honduras Progreso | 4:1 | ||||
| 8. Round | 29/10/2020 | Honduras Progreso | - | Real España | 0:3 | ||||
| 13. Round | 14/11/2020 | Honduras Progreso | - | Real Sociedad | 1:2 | ||||
| 10. Round | 23/11/2020 | Lobos UPNFM | - | Honduras Progreso | 0:1 | ||||
| 11. Round | 26/11/2020 | Honduras Progreso | - | Motagua | 0:5 | ||||
| 12. Round | 29/11/2020 | Olimpia | - | Honduras Progreso | 5:0 | ||||
| 14. Round | 12/12/2020 | Real de Minas | - | Honduras Progreso | 3:4 |  |
Colombia