| 1. Round | 06/02/2022 | San Francisco FC | - | Veraguas United | 0:1 | ||||
| 6. Round | 09/03/2022 | San Francisco FC | - | Árabe Unido | 0:0 | ||||
| 7. Round | 13/03/2022 | Alianza | - | San Francisco FC | 2:1 | ||||
| 8. Round | 20/03/2022 | Tauro FC | - | San Francisco FC | 1:0 | ||||
| 9. Round | 26/03/2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 13. Round | 24/04/2022 | Independiente de La Chorrera | - | San Francisco FC | 1:4 | ||||
| 14. Round | 27/04/2022 | San Francisco FC | - | Atlético Chiriquí | 2:2 | ||||
| 15. Round | 30/04/2022 | UD Universitario | - | San Francisco FC | 0:1 | ||||
| 12. Round | 05/05/2022 | Veraguas United | - | San Francisco FC | 0:2 |
Panama