| 1. Round | 14/01/2023 | UD Universitario | - | San Francisco FC | 0:1 |  |
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| 2. Round | 21/01/2023 | UMECIT | - | San Francisco FC | 1:1 |  |
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| 3. Round | 28/01/2023 | San Francisco FC | - | Independiente de La Chorrera | 2:2 | |
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| 4. Round | 04/02/2023 | San Francisco FC | - | Herrera FC | 0:0 | ||||
| 5. Round | 11/02/2023 | Atlético Chiriquí | - | San Francisco FC | 3:1 | |
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| 6. Round | 15/02/2023 | San Francisco FC | - | Potros del Este | 1:3 | ||||
| 7. Round | 25/02/2023 | San Francisco FC | - | Sporting San Miguelito | 1:1 | ||||
| 8. Round | 04/03/2023 | San Francisco FC | - | Plaza Amador | 1:1 | ||||
| 9. Round | 12/03/2023 | Tauro FC | - | San Francisco FC | 2:0 | ||||
| 10. Round | 19/03/2023 | Alianza | - | San Francisco FC | 0:0 | ||||
| 11. Round | 25/03/2023 | Árabe Unido | - | San Francisco FC | 0:0 | ||||
| 12. Round | 01/04/2023 | San Francisco FC | - | UD Universitario | 2:1 | ||||
| 13. Round | 05/04/2023 | San Francisco FC | - | UMECIT | 0:0 | ||||
| 14. Round | 15/04/2023 | Independiente de La Chorrera | - | San Francisco FC | 3:0 |
Panama