| 1. Round | 16/01/2022 | Sololá FC | - | Cobán Imperial | 0:0 | ||||
| 2. Round | 22/01/2022 | Cobán Imperial | - | Comunicaciones | 2:0 | ||||
| 4. Round | 02/02/2022 | Cobán Imperial | - | Xelaju MC | 3:1 | ||||
| 6. Round | 10/02/2022 | Antigua GFC | - | Cobán Imperial | 0:1 | ||||
| 7. Round | 12/02/2022 | Cobán Imperial | - | Iztapa | 2:0 | ||||
| 9. Round | 27/02/2022 | Cobán Imperial | - | Achuapa | 0:1 |  |
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| 10. Round | 02/03/2022 | Santa Lucía | - | Cobán Imperial | 2:1 | ||||
| 11. Round | 06/03/2022 | Cobán Imperial | - | Deportivo Guastatoya | 0:0 | ||||
| 12. Round | 12/03/2022 | Cobán Imperial | - | Sololá FC | 2:1 | ||||
| 14. Round | 26/03/2022 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 16. Round | 09/04/2022 | Cobán Imperial | - | Nueva Concepción | 5:1 |  |
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| 19. Round | 13/04/2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 17. Round | 16/04/2022 | Cobán Imperial | - | Antigua GFC | 0:0 |
Guatemala