| 1. Round | 17/01/2021 | Atlético Junior | - | Independiente Medellín | 1:0 | ||||
| 2. Round | 23/01/2021 | Independiente Medellín | - | Patriotas FC | 2:1 | ||||
| 3. Round | 01/02/2021 | Atlético Bucaramanga | - | Independiente Medellín | 0:1 | ||||
| 5. Round | 07/02/2021 | Deportes Tolima | - | Independiente Medellín | 2:1 |  |
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| 14. Round | 24/03/2021 | América de Cali | - | Independiente Medellín | 1:2 | ||||
| 18. Round | 10/04/2021 | Independiente Medellín | - | Alianza Petrolera | 2:2 |
Colombia