| 2. Round | 09/09/2016 | FC Schalke 04 | - | Bayern München | 0:2 | ||||
| 3. Round | 18/09/2016 | Hertha BSC | - | FC Schalke 04 | 2:0 | ||||
| 4. Round | 21/09/2016 | FC Schalke 04 | - | 1. FC Köln | 1:3 | ||||
| 7. Round | 15/10/2016 | FC Augsburg | - | FC Schalke 04 | 1:1 |  |
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| 9. Round | 29/10/2016 | Borussia Dortmund | - | FC Schalke 04 | 0:0 | ||||
| 10. Round | 06/11/2016 | FC Schalke 04 | - | Werder Bremen | 3:1 | ||||
| 12. Round | 27/11/2016 | FC Schalke 04 | - | SV Darmstadt 98 | 3:1 | ||||
| 13. Round | 03/12/2016 | RB Leipzig | - | FC Schalke 04 | 2:1 | ||||
| 14. Round | 11/12/2016 | FC Schalke 04 | - | Bayer Leverkusen | 0:1 | ||||
| 15. Round | 17/12/2016 | FC Schalke 04 | - | SC Freiburg | 1:1 |  |
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| 16. Round | 20/12/2016 | Hamburger SV | - | FC Schalke 04 | 2:1 | ||||
| 17. Round | 21/01/2017 | FC Schalke 04 | - | FC Ingolstadt 04 | 1:0 | ||||
| 18. Round | 27/01/2017 | FC Schalke 04 | - | Eintracht Frankfurt | 0:1 | ||||
| 23. Round | 04/03/2017 | Bor. Mönchengladbach | - | FC Schalke 04 | 4:2 | ||||
| 24. Round | 12/03/2017 | FC Schalke 04 | - | FC Augsburg | 3:0 | ||||
| 27. Round | 04/04/2017 | Werder Bremen | - | FC Schalke 04 | 3:0 | ||||
| 32. Round | 07/05/2017 | SC Freiburg | - | FC Schalke 04 | 2:0 |
Ukraine
