| 1. Round | 25/07/2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Round | 30/07/2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 3. Round | 06/08/2021 | Metalist 1925 Kharkiv | - | Chernomorets Odessa | 3:2 | ||||
| 4. Round | 13/08/2021 | Shakhtar Donetsk | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 5. Round | 20/08/2021 | Vorskla Poltava | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 6. Round | 28/08/2021 | Metalist 1925 Kharkiv | - | SK Dnipro-1 | 1:2 | ||||
| 7. Round | 11/09/2021 | Metalist 1925 Kharkiv | - | Dinamo Kiev | 0:2 | ||||
| 8. Round | 19/09/2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | ||||
| 10. Round | 03/10/2021 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 |  |
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| 11. Round | 16/10/2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 12. Round | 22/10/2021 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 | ||||
| 13. Round | 31/10/2021 | Metalist 1925 Kharkiv | - | Zorya Lugansk | 1:6 | ||||
| 14. Round | 05/11/2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 15. Round | 22/11/2021 | NK Veres | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Round | 04/12/2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 |
Ukraine