| 1. Round | 17/01/2021 | Leones Negros | - | Coyotes de Tlaxcala | 1:1 | ||||
| 2. Round | 21/01/2021 | TM Fútbol Club | - | Leones Negros | 0:0 | ||||
| 5. Round | 12/02/2021 | Leones Negros | - | Venados FC | 1:1 | ||||
| 6. Round | 17/02/2021 | Correcaminos UAT | - | Leones Negros | 0:2 |  |
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| 9. Round | 12/03/2021 | Leones Negros | - | Cimarrones de Sonora | 1:1 | ||||
| 10. Round | 15/03/2021 | Leones Negros | - | Tepatitlán | 0:1 | ||||
| 11. Round | 26/03/2021 | Atlético Morelia | - | Leones Negros | 2:1 | ||||
| 12. Round | 29/03/2021 | Mineros de Zacatecas | - | Leones Negros | 1:0 | ||||
| 13. Round | 02/04/2021 | Leones Negros | - | Club Celaya | 3:1 | ||||
| 14. Round | 08/04/2021 | Cancún FC | - | Leones Negros | 2:0 | ||||
| 15. Round | 14/04/2021 | Leones Negros | - | Alebrijes de Oaxaca | 1:1 |
Colombia