| 1. Round | 19/08/2010 | Trujillanos FC | - | Estudiantes de Mérida | 0:1 | ||||
| 3. Round | 23/08/2010 | Trujillanos FC | - | Deportivo Táchira | 1:3 |  |
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| 4. Round | 29/08/2010 | Trujillanos FC | - | Mineros de Guayana | 1:1 | ||||
| 5. Round | 12/09/2010 | Carabobo FC | - | Trujillanos FC | 0:0 |  |
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| 6. Round | 19/09/2010 | Trujillanos FC | - | Caracas FC | 2:0 | |
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| 7. Round | 24/09/2010 | Atlético Venezuela | - | Trujillanos FC | 1:4 | ||||
| 8. Round | 03/10/2010 | Trujillanos FC | - | Monagas | 1:0 | ||||
| 9. Round | 14/10/2010 | Caroni FC | - | Trujillanos FC | 1:0 | ||||
| 10. Round | 24/10/2010 | Trujillanos FC | - | Zamora FC | 2:0 | |
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| 11. Round | 31/10/2010 | Deportivo Lara | - | Trujillanos FC | 0:1 | ||||
| 12. Round | 07/11/2010 | Trujillanos FC | - | Atlético El Vigía | 3:2 | |
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| 13. Round | 14/11/2010 | Zulia FC | - | Trujillanos FC | 0:0 | ||||
| 14. Round | 21/11/2010 | Trujillanos FC | - | Aragua FC | 2:0 | ||||
| 15. Round | 28/11/2010 | Real Esppor Club | - | Trujillanos FC | 1:1 |
Venezuela