| 1. Round | 16/01/2022 | CD Águila | - | Jocoro FC | 0:0 | ||||
| 2. Round | 22/01/2022 | Jocoro FC | - | Alianza | 3:2 |  |
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| 3. Round | 26/01/2022 | Jocoro FC | - | FAS | 2:2 | ||||
| 4. Round | 30/01/2022 | Santa Tecla FC | - | Jocoro FC | 3:0 | |
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| 8. Round | 20/02/2022 | AD Chalatenango | - | Jocoro FC | 1:0 | ||||
| 9. Round | 23/02/2022 | Jocoro FC | - | Luis Ángel Firpo | 1:1 | ||||
| 10. Round | 27/02/2022 | Platense Zacatecoluca | - | Jocoro FC | 2:0 | |
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| 14. Round | 23/03/2022 | FAS | - | Jocoro FC | 2:1 | ||||
| 18. Round | 17/04/2022 | Isidro Metapán | - | Jocoro FC | 3:0 | ||||
| 19. Round | 24/04/2022 | Jocoro FC | - | AD Chalatenango | 6:5 | ||||
| 22. Round | 07/05/2022 | Once Municipal | - | Jocoro FC | 0:1 | |
Colombia