| 1. Round | 24/07/2021 | Havre AC | - | EA Guingamp | 0:0 | ||||
| 2. Round | 31/07/2021 | EA Guingamp | - | Valenciennes FC | 1:1 | ||||
| 3. Round | 07/08/2021 | Grenoble Foot 38 | - | EA Guingamp | 0:0 |  |
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| 5. Round | 23/08/2021 | AJ Auxerre | - | EA Guingamp | 1:2 | ||||
| 6. Round | 28/08/2021 | EA Guingamp | - | AC Ajaccio | 1:1 | ||||
| 7. Round | 11/09/2021 | Paris FC | - | EA Guingamp | 0:1 | ||||
| 8. Round | 18/09/2021 | Chamois Niortais | - | EA Guingamp | 2:0 | ||||
| 15. Round | 06/11/2021 | EA Guingamp | - | SC Bastia | 2:3 | ||||
| 22. Round | 22/01/2022 | Amiens SC | - | EA Guingamp | 3:0 | ||||
| 35. Round | 22/04/2022 | Dijon FCO | - | EA Guingamp | 3:3 | ||||
| 37. Round | 07/05/2022 | USL Dunkerque | - | EA Guingamp | 1:3 | ||||
| 38. Round | 14/05/2022 | EA Guingamp | - | Havre AC | 2:1 |
France
Congo DR