| 1. Round | 02/08/2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 | ||||
| 2. Round | 08/08/2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | ||||
| 3. Round | 15/08/2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 4. Round | 23/08/2021 | Club Deportivo Ocotal | - | Diriangén FC | 1:1 | ||||
| 5. Round | 29/08/2021 | Club Deportivo Ocotal | - | Real Madriz | 2:1 | ||||
| 7. Round | 13/09/2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | ||||
| 8. Round | 20/09/2021 | Club Deportivo Ocotal | - | UNAN Managua | 1:2 |  |
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| 6. Round | 23/09/2021 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 9. Round | 26/09/2021 | Club Deportivo Ocotal | - | Real Estelí FC | 1:2 | ||||
| 10. Round | 03/10/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:0 | ||||
| 11. Round | 10/10/2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | ||||
| 13. Round | 22/10/2021 | Diriangén FC | - | Club Deportivo Ocotal | 3:0 | ||||
| 14. Round | 25/10/2021 | Real Madriz | - | Club Deportivo Ocotal | 1:1 | ||||
| 15. Round | 01/11/2021 | Club Deportivo Ocotal | - | Juventus Managua | 1:0 | |
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| 16. Round | 05/11/2021 | Club Deportivo Ocotal | - | Managua FC | 1:0 |
Nicaragua