| 2. Round | 30/07/2021 | FC Liefering | - | SKN St. Pölten | 2:1 | ||||
| 1. Round | 03/08/2021 | SKN St. Pölten | - | Rapid Wien (A) | 1:2 | ||||
| 3. Round | 06/08/2021 | FC Blau Weiß Linz | - | SKN St. Pölten | 1:1 |  |
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| 4. Round | 15/08/2021 | SKN St. Pölten | - | SV Horn | 1:3 | ||||
| 5. Round | 20/08/2021 | Floridsdorfer AC | - | SKN St. Pölten | 2:0 | ||||
| 6. Round | 27/08/2021 | SKN St. Pölten | - | Austria Wien (A) | 2:0 | ||||
| 9. Round | 24/09/2021 | SKN St. Pölten | - | SKU Amstetten | 4:0 | |
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| 10. Round | 01/10/2021 | FC Juniors OÖ | - | SKN St. Pölten | 1:3 | ||||
| 11. Round | 15/10/2021 | SKN St. Pölten | - | Grazer AK | 6:1 | ||||
| 12. Round | 24/10/2021 | Kapfenberger SV 1919 | - | SKN St. Pölten | 2:0 | ||||
| 13. Round | 31/10/2021 | SKN St. Pölten | - | Austria Lustenau | 1:1 | ||||
| 15. Round | 19/11/2021 | SKN St. Pölten | - | Vorwärts Steyr | 1:1 | ||||
| 17. Round | 20/02/2022 | SKN St. Pölten | - | FC Liefering | 2:0 | ||||
| 21. Round | 18/03/2022 | Austria Wien (A) | - | SKN St. Pölten | 0:0 | ||||
| 22. Round | 03/04/2022 | FC Dornbirn | - | SKN St. Pölten | 3:4 | |
South Korea